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受験生向けイベント
WEB出願

教員紹介 詳細

庭野吉己

学位

博士（農学）、博士（医学）

学歴

京都大学 農学部 卒業
京都大学大学院 農学研究科修士課程 修了

専門分野

生理学、薬理学、栄養学、生化学、分子生物学

研究テーマ

活性酸素・フリーラジカル制御に関する研究

所属学会

日本農芸化学会、日本栄養・食糧学会、日本防菌防黴学会、日本酸化ストレス学会、日本機能水学会、東北大学歯学会

主な担当科目

生理学、薬理学、臨床栄養学、基礎からの生物・化学、疫学

主な業績

原著論文・総説

  1. Shirato M, Takida Y, Kanno T, Matsuura H, Niwano Y, Minamide H, Keisuke Nakamura K.: Mutagenicity assessment of high‐power 1.6‐THz pulse laser radiation. Photochem Photobiol, 100:146-158, 2023
  2. Niwano Y, Kohzaki H, Shirato M, Shishido S, Nakamura K.: Metabolic fate of orally ingested proanthocyanidins through the digestive tract. Antioxidants (Basel), 12:17, 2023
  3. Shirato M, Nakamura K, Tenkumo T, Niwano Y, Kanno T, Sasaki K, Lingström P, Örtengren U.: Inhibition of tooth demineralization caused by Streptococcus mutans biofilm via antimicrobial treatment using hydrogen peroxide photolysis. Clin Oral Investig, 27:739-750, 2023
  4. Miyano R, Matsuo H, Mokudai T, Higo M, Nonaka K, Niwano Y, Shiomi K, Takahashi Y, Ōmura S, Nakashima T.: New nitrogen-compounds, penicidones E and F, produced by the fungal strain Oidiodendron sp. FKI-7498. Biosci Biotechnol Biochem, 87:38-44, 2022
  5. Niwano Y, Kohzaki H, Shirato M, Shishido S, Nakamura K.: Putative mechanisms underlying the beneficial effects of polyphenols in murine models of metabolic disorders in relation to gut microbiota. Curr Issues Mol Biol, 44:1353-1375, 2022
  6. Niwano Y, Kohzaki H, Shirato M, Shishido S, Nakamura K: Anti-osteoporotic mechanisms of polyphenols elucidated based on in vivo studies using ovariectomized animals. Antioxidants (Basel), 11:217, 2022
  7. Tenkumo T, Aobulikasimu A, Asou Y, Shirato M, Shishido S, Kanno T, Niwano Y, Sasaki K, Nakamura K: Proanthocyanidin-rich grape seed extract improves bone loss, bone healing, and implant osseointegration in ovariectomized animals. Sci Rep, 10:8812, 2020
  8. Nakamura K, Shirato M, Shishido S, Niwano Y, Kanno T, Sasaki K, Lingström P, Örtengren U: Reactions of dental pulp to hydrogen peroxide photolysis-based antimicrobial chemotherapy under ultraviolet-A irradiation in rats. J Photochem Photobiol B, Biology, 212:112042, 2020
  9. Matsuo H, Hirose T, Mokudai T, Nonaka K, Niwano Y, Sunazuka T, Takahashi Y, Ōmura S, Nakashima T: Absolute structure and anti-oxidative activity of chaetochiversin C isolated from fungal strain Neocosmospora sp. FKI-7792 by physicochemical screening. J Gen Appl Microbiol, 26:181-187, 2020. 2020
  10. Miyano R, Matsuo H, Mokudai T, Noguchi Y, Higo M, Nonaka K, Niwano Y, Sunazuka T, Shiomi K, Takahashi Y, Ōmura S, Nakashima T: Trichothioneic acid, a new antioxidant compound produced by the fungal strain Trichoderma virens FKI-7573. J Biosci Bioeng, 129:508-513, 2020
  11. Matsuo H, Mokudai T, Higo M, Nonaka K, Nagano Y, Nagahama T, Niwano Y, Takahashi Y, Ōmura S, Nakashima T: Cipralphelin, a new anti-oxidative N-cinnamoyl tripeptide produced by the deep sea-derived fungal strain Penicillium brevicompactum FKJ-0123. J Antibiot, 72:775-778, 2019
  12. Shirato M, Nakamura K, Tenkumo T, Kano Y, Ishiyama K, Kanno T, Sasaki K, Niwano Y, Matsuura H: Oral mucosal irritation potential of antimicrobial chemotherapy involving hydrogen peroxide photolysis with high-power laser irradiation for the treatment of periodontitis. J Photochem Photobiol B, Biology, 201:111633, 2019
  13. Niwano Y, Iwasawa A, Tsubota K, Ayaki M, Negishi K: Protective effects of blue light-blocking shades on phototoxicity in human ocular surface cells. BMJ Open Ophthalmol, 4: e000217, 2019
  14. Nakamura K, Shirato M, Tenkumo T, Kanno T, Westerlund A, Örtengren U, Sasaki K, Niwano Y: Hydroxyl radicals generated by hydrogen peroxide photolysis recondition biofilm-contaminated titanium surfaces for subsequent osteoblastic cell proliferation. Sci Rep, 9:4688, 2019
  15. Ueda T, Ueda K, Ito K, Ogasawara K, Kanetaka H, Mokudai T, Niwano Y, Narushima T: Visible-light-responsive antibacterial activity of Au-incorporated TiO2 layers formed on Ti-(0-10)at%Au alloys by air oxidation. J Biomed Mater Res Part A, 107:991-1000, 2019
  16. 庭野 吉己：医療・食品・環境分野で注目される抗菌技術 光線力学抗菌化学療法(バイオフィルム、耐性菌)。防菌防黴誌 47(3):125-131, 2019
  17. Nakamura K, Ankyu S, Nilsson F, Kanno T, Niwano Y, Vult von Steyern P, Örtengren U: Critical considerations on load-to-failure test for monolithic zirconia molar crowns. J Mech Behav Biomed Mater, 87:180-189, 2018
  18. Nakazawa K, Nakamura K, Harada A, Shirato M, Inagaki R, Örtengren U, Kanno T, Niwano Y, Egusa H: Surface properties of dental zirconia ceramics affected by ultrasonic scaling and low-temperature degradation. PloS one 13:e0203849, 2018
  19. Miyano R, Matsuo H, Nonaka K, Mokudai T, Niwano Y, Shiomi K, Takahashi Y, Ōmura S, Nakashima T: Pochoniolides A and B, new antioxidants from the fungal strain Pochonia chlamydosporia var. spinulospora FKI-7537. J Biosci Bioeng, 126:661-666, 2018
  20. Shishido S, Miyano R, Nakashima T, Matsuo H, Iwatsuki M, Nakamura K, Kanno T, Egusa H, Niwano Y: A novel pathway for the photooxidation of catechin in relation to its prooxidative activity. Sci Rep, 8:12888, 2018
  21. Ankyu S, Nakamura K, Harada A, Inagaki R, Kastuda Y, Kanno T, Niwano Y, Örtengren U, Egusa H: Influence of microscale expansion and contraction caused by thermal and mechanical fatigue on retentive strength of CAD/CAM-generated resin-based composite crowns. J Mech Behav Biomed Mater, 86:89-97, 2018
  22. Jin G, Asou Y, Ishiyama K, Okawa A, Kanno T, Niwano Y: Proanthocyanidin-rich grape seed extract modulates intestinal microbiota in ovariectomized mice. J Food Sci, 83(4):1149-1152, 2018
  23. Kimura T, Tajima A, Inahashi Y, Iwatsuki M, Kasai H, Mokudai T, Niwano Y, Shiomi K, Takahashi Y, Ōmura S, Nakashima T: Mumiamicin: Structure and bioactivity of a new furan fatty acid from Mumia sp. YSP-2-79. J Gen Appl Microbiol, 64(2):62-67, 2018
  24. Sheng H, Ogawa T，Niwano Y，Sasaki K，Tachibana K: Effects of polyphenols on doxorubicin-induced oral keratinocyte cytotoxicity and anticancer potency against oral cancer cells. J Oral Pathol Med, 47(4):368-374, 2018
  25. Jin G, Aobulikasimu A, Piao J, Aibibula Z, Koga D, Ochi H, Ishiyama K, Kanno T, Niwano Y, Okawa A, Asou Y: Proanthocyanidin-rich grape seed extract prevent estrogen deficiency-induced metabolic disorders. J Med Dent Sci, 62(2):45-50, 2018
  26. Niwano Y, Konno K, Matayoshi T, Nakamura, K., Kanno, T., Sasaki, K.: Oral mucosal irritation study in hamster to evaluate a therapeutic apparatus using hydrogen peroxide photolysis for periodontitis treatment. Regul Toxicol Pharmacol, 90:206-213, 2017
  27. Kanno T, Nakamura K, Ishiyama K, Yamada Y, Shirato M, Niwano Y, Kayaba C, Ikeda K, Takagi A, Yamaguchi T., Sasaki K: Adjunctive antimicrobial chemotherapy based on hydrogen peroxide photolysis in non-surgical treatment for moderate to severe periodontitis: a randomized clinical trial. Sci Rep, 7(1):12247, 2017
  28. Shirato M, Nakamura K, Kanno T, Lingström P, Niwano Y, Örtengren U: Time-kill kinetic analysis of antimicrobial chemotherapy based on hydrogen peroxide photolysis against Streptococcus mutans biofilm. J Photochem Photobiol B, Biology, 173:434-440, 2017
  29. Nakamura K, Shirato M, Kanno T, Lingström P, Örtengren U, Niwano Y: Photo-irradiated caffeic acid exhibits antimicrobial activity against Streptococcus mutans biofilms via hydroxyl radical formation. Sci Rep, 7(1):6353, 2017
  30. 冨並 香菜子, 金高 弘恭, 目代 貴之, 庭野 吉己 : 低温大気圧プラズマ照射により生成される活性酸素種の定量評価。東北大学歯学雑誌 35/36(2/1): 61-69, 2017
  31. Tominami K, Kanetaka H, Sasaki S, Mokudai T, Kaneko T, Niwano Y: Cold atmospheric plasma enhances osteoblast differentiation. PLoS One, 12(7):e0180507, 2017
  32. Niwano Y, Tada M, Tsukada M: Antimicrobial intervention by photoirradiation of grape pomace extracts via hydroxyl radical generation. Front Physiol, 8:728, 2017
  33. Sato E, Mori T, Mishima E, Suzuki A, Sugawara S, Kurasawa N, Saigusa D, Miura D, Morikawa-Ichinose T, Saito R, Oba-Yabana I, Oe Y, Kisu K, Naganuma E, Koizumi K, Mokudai T, Niwano Y, Kudo T, Suzuki C, Takahashi N, Sato H, Abe T, Niwa T, Ito S: Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease. Sci Rep, 6:36618, 2016
  34. Sato H, Niwano Y, Nakamura K, Mokudai T, Ikai H, Kanno T, Egusa H: Efficacy and safety of a therapeutic apparatus using hydrogen peroxide photolysis to treat dental and periodontal infectious diseases. J Toxicol Sci, 41(6):793-799, 2016
  35. Ishiyama K, Nakamura K, Kanno T, Niwano Y: Bactericidal action of photodynamic antimicrobial chemotherapy (PACT) with photosensitizers used as plaque-disclosing agents against experimental biofilm. Biocontrol Sci, 21(3):187-191, 2016
  36. Nakamura K, Shirato M, Kanno T, Örtengren U, Lingström P, Niwano Y: Antimicrobial activity of hydroxyl radicals generated by hydrogen peroxide photolysis against Streptococcus mutans biofilm. Int J Antimicrob Agents, 48(4):373-380, 2016
  37. Tsukada M, Sheng H, Kamachi T, Niwano Y: Microbicidal action of photoirradiated aqueous extracts from wine lees. J Food Sci Technol, 53(7):3020-3027, 2016
  38. Ankyu S, Nakamura K, Harada A, Hong G, Kanno T, Niwano Y, Örtengren U, Egusa H: Fatigue analysis of computer-aided design/computer-aided manufacturing disilicate glass-ceramic. Eur J Oral Sci, 124(4):387-395, 2016
  39. Tsukada M, Nakashima T, Kamachi T, Niwano Y: Prooxidative potential of photo-irradiated aqueous extracts of grape pomace, a recyclable resource from winemaking process. PLoS One, 11(6):e0158197, 2016
  40. Tsukada M, Sheng H, Tada M, Mokudai T, Oizumi S, Kamachi T, Niwano Y: Bactericidal action of photo-irradiated aqueous extract from residue of crushed grape for wine preparation. Biocontrol Sci, 21(2):113-121, 2016
  41. Nakamura K, Harada A, Ono M, Shibasaki H, Kanno T, Niwano Y, Milleding P, Örtengren U: Effect of low-temperature degradation on the mechanical and microstructural properties of tooth-colored 3Y-TZP ceramics. J Mech Behav Biomed Mater, 53:301-311, 2016
  42. 庭野吉己：活性酸素による微生物制御．防菌防黴誌 44(3):119-124, 2016
  43. Tada M, Niwano Y, Kohno M: Generation mechanism of deferoxamine radical by tyrosine-tyrosinase reaction. Anal Sci, 31(9):911-916, 2015
  44. Nakamura K, Katsuda Y, Ankyu S, Harada A, Tenkumo T, Kanno T, Niwano Y, Egusa H, Milleding P, Örtengren U: Cutting efficiency of diamond burs operated with electric high-speed dental handpiece on zirconia. Eur J Oral Sci, 123:375-380, 2015
  45. Katsuda Y, Niwano Y, Nakashima T, Mokudai T, Nakamura K, Oizumi S, Kanno T, Kanetaka H, Egusa H: Cytoprotective effects of grape seed extract on human gingival fibroblasts in relation to its antioxidant potential. PLos ONE, 10(8): e0134704, 2015
  46. Sheng H, Nakamura K, Kanno T, Sasaki K, Niwano Y : Bactericidal effect of photolysis of H2O2 in combination with sonolysis of water via hydroxyl radical generation. PLoS ONE, 10(7): e0132445, 2015
  47. Nakamura K, Harada A, Kanno T, Inagaki R, Niwano Y, Milleding P, Örtengren U: The influence of low-temperature degradation and cyclic　loading on the fracture　resistance of monolithic zirconia molar crowns. J Mech Behav Biomed Mater, 47:49-56, 2015
  48. Nakamura K, Ishiyama K, Sheng H, Ikai H, Kanno T, Niwano Y: Bactericidal activity and mechanism of photo-irradiated polyphenols against Gram-positive and -negative bacteria. J Agric Food Chem, 63(35):7707-7713, 2015
  49. Harada A, Nakamura K, Kanno T, Inagaki R, Örtengren U, Niwano Y, Sasaki K, Egusa H: Fracture resistance of CAD/CAM-generated composite resin-based molar crowns. Eur J Oral Sci, 123(2):122-129, 2015
  50. Nakamura K, Harada A, Inagaki R, Kanno T, Niwano Y, Milleding P, Örtengren U: Fracture resistance of monolithic zirconia molar crowns with reduced thickness. Acta Odontol Scand, 30:1-7, 2015
  51. Mokudai T, Kanno T, Niwano Y: Postantifungal-like effect of sublethal treatment of Candida albicans with acid-electrolyzed water. Arch Oral Biol, 60(3):479-487, 2015
  52. Mokudai T, Kanno T, Niwano Y: Involvement of reactive oxygen species in the cytotoxic effect of acid-electrolyzed water. J Toxicol Sci, 40(1):13-19, 2015
  53. Toki T, Nakamura K, Kurauchi M, Kanno T, Katsuda Y, Ikai H, Hayashi E, Egusa H, Sasaki K, Niwano Y: Synergistic interaction between wavelength of light and concentration of H2O2 in bactericidal activity of photolysis of H2O2. J Biosci Bioeng, 119(3):358-362, 2015
  54. Kurauchi M, Niwano Y, Shirato M, Kanno T, Nakamura K, Egusa H, Sasaki K: Cytoprotective effect of short-term pretreatment with proanthocyanidin on human gingival fibroblasts exposed to harsh environmental conditions. PLoS ONE, 9(11):e113403, 2014
  55. Tada M, Kohno M, Niwano Y: Alleviation effect of arbutin on oxidative stress generated through tyrosinase reaction with L-tyrosine and L-DOPA. BMC Biochem, 15:23, 2014
  56. Tsuruya M, Niwano Y, Nakamura K, Kanno T, Egusa H, Sasaki K: Acceleration of proliferative response of mouse fibroblasts by short-time pretreatment with polyphenols. Appl Biochem Biotechnol, 174(6):2223-2235, 2014
  57. Niwano Y, Kanno T, Iwasawa A, Ayaki M, Tsubota K: Blue light injures corneal epithelial cells in the mitotic phase in vitro. Br J Ophthalmol, 98(7):990-992, 2014
  58. Sheng H, Nakamura K, Kanno T, Sasaki K, Niwano Y: Microbicidal activity of artificially generated hydroxyl radicals. Interface Oral Health Sci, 2014, pp203-215, 2014
  59. Niwano Y, Iwasawa A, Ayaki M.: Ocular surface cytotoxicity and safety evaluation of tafluprost, a recently developed anti-glaucoma prostaglandin analogue. Ophthalmol Eye Dis, 6:5-12, 2014
  60. Ikai H, Odashima Y, Kanno T, Nakamura K, Shirato M, Sasaki K, Niwano Y: In vitro evaluation of the risk of inducing bacterial resistance to disinfection treatment with photolysis of hydrogen peroxide. PLoS ONE, 8(11):e81316, 2013
  61. Nakahara T, Harada A, Yamada Y, Odashima Y, Nakamura K, Inagaki R, Kanno T, Sasaki K, Niwano Y: Influence of a new denture cleaning technique utilizing photolysis of H2O2 on mechanical properties and color stability of acrylic denture base resin. Dent Mater J, 32(4):529-536, 2013
  62. Iwasawa A, Ayaki M, Niwano Y: Cell viability score (CVS) as a good indicator of critical concentration of benzalkonium chloride for toxicity in cultured ocular surface cell lines. Regul Toxicol Pharmacol, 66(2):177-183, 2013
  63. Ikai H, Nakamura K, Kanno T, Shirato M, Meirelles L, Sasaki K, Niwano Y: Synergistic effect of proanthocyanidin on the bactericidal action of the photolysis of H2O2. Biocontrol Sci, 18(2):137-141, 2013
  64. Nakamura K, Shirato M, Ikai H, Kanno T, Sasaki K, Kohno M, Niwano Y: Photo-irradiation of proanthocyanidin as a new disinfection technique via reactive oxygen species formation, PLoS ONE, 8(3):e60053, 2013
  65. Oyamada A, Ikai H, Nakamura K, Hayashi E, Kanno T, Sasaki K, Niwano Y: In vitro bactericidal activity of photo-irradiated oxydol products via hydroxyl radical generation. Biocontrol Sci, 18(2):83-88, 2013
  66. Niwano Y, Iwasawa A, Ayaki M: Safety evaluation of ophthalmic moxifloxacin, an antibiotic of the fourth-generation fluoroquinolone family. J Symptoms Signs, 2(6):468-474, 2013
  67. Ayaki M, Iwasawa A, Niwano Y: Comparative assessment of the cytotoxicity of six anti-inflammatory eyedrops in four cultured ocular surface cell lines, as determined by cell viability scores. Clin Ophthalmol, 6:1879-1884, 2012
  68. Nakamura K, Yamada Y, Ikai H, Kanno T, Sasaki K, Niwano Y: Bactericidal action of photo-irradiated gallic acid via reactive oxygen species formation. J Agric Food Chem, 60(40):10048-10054, 2012
  69. Beppu F, Hosokawa M, Niwano Y, Miyashita K: Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-Ay mice. Lipids Health Dis, 11(1):112, 2012
  70. Mokudai T, Nakamura K, Kanno T, Niwano Y: Presence of hydrogen peroxide, a source of hydroxyl radicals, in acid electrolyzed water. PLoS ONE, 7(9):e46392, 2012
  71. Nakamura K, Yamada Y, Takeda Y, Mokudai T, Ikai H, Inagaki R, Kanno T, Sasaki K, Kohno M, Niwano Y: Corrosive effect of hydroxyl radical generated by photolysis of H2O2 on dental metals. Dent Mater J, 31(6):941-946, 2012
  72. Ishiyama K, Nakamura K, Ikai H, Kanno T, Kohno M, Sasaki K, Niwano Y: Bactericidal action of photogenerated singlet oxygen from photosensitizers used in plaque disclosing agents. PLoS ONE, 7(5):e37871, 2012
  73. Hayashi E, Mokudai T, Yamada Y, Nakamura K, Kanno T, Sasaki K, Niwano Y: In vitro and in vivo anti-Staphylococcus aureus activities of a new disinfection system utilizing photolysis of hydrogen peroxide. J Biosci Bioeng, 114(2):193-197, 2012
  74. Ayaki M, Iwasawa A, Niwano Y: Cell viability score as an integrated indicator for cytotoxicity of benzalkonium chloride-containing antiglaucoma eyedrops. Biocontrol Sci, 17(3):121-128, 2012
  75. Ayaki M, Iwasawa A, Niwano Y: Comparative study of in vitro ocular surface cytotoxicity for fixed combination of 0.5% timolol/1% dorzolamide eyedrop and its components with 0.005% benzalkonium chloride. Biocontrol Sci, 17(3):115-120, 2012
  76. Yamada Y, Mokudai T, Nakamura K, Hayashi E, Kawana Y, Kanno T, Sasaki K, Niwano Y: Topical treatment of oral cavity and wounded skin with a new disinfection system utilizing photolysis of hydrogen peroxide in rats. J Toxicol Sci, 37(2):329-335, 2012
  77. Ayaki M, Iwasawa A, Niwano Y: In vitro assessment of six topical antibiotics cytotoxicity to　four cultured ocular surface cell lines. Biocontrol Sci, 17(2):93-99, 2012
  78. Kanno T, Nakamura K, Ikai H, Hayashi E, Shirato M, Mokudai T, Iwasawa A, Niwano Y, Kohno M, Sasaki K: Novel denture cleaning system based on hydroxyl radical disinfection. Int J Prosthodont, 25(4):376-380, 2012
  79. Yaekashiwa N, Sato E, Nakamura K, Iwasawa A, Kudo A, Kanno T, Kohno M, Niwano Y: Determination of reactive oxygen species generated by phorbol 12-myristate 13-acetate-stimulated oral polymorphonuclear cells from healthy human volunteers without any dental problems. Arch Oral Biol, 57:636-641, 2012
  80. Nakamura K, Kanno T, Mokudai T, Iwasawa A, Niwano Y, Kohno M: Microbial resistance in relation to catalase activity to oxidative stress induced by photolysis of H2O2. Microbiol Immunol, 56(1):48-55, 2012
  81. Shirato M , Ikai H, Nakamura K, Hayashi E, Kanno T, Sasaki K, Kohno M, Niwano Y: Synergistic effect of thermal energy on bactericidal action of photolysis of H2O2 in relation to acceleration of hydroxyl radical generation, Antimicrob Agents Chemother, 56(1):295-301, 2012
  82. Iwasawa A, Niwano Y, Kohno M, Ayaki M: Virucidal activity of alcohol-based hand rub disinfectants. Biocontrol Sci, 17(1):45-59, 2012
  83. Kanno T, Nakamura K, Ikai H, Kikuchi K, Sasaki K, Niwano Y: Literature review of the role of hydroxyl radicals in chemically-induced mutagenicity and carcinogenicity for the risk assessment of a disinfection system utilizing photolysis of hydrogen peroxide. J Clin Biochem Nutr, 51(1):9-14, 2012
  84. Iwasawa A, Niwano Y, Kohno M, Ayaki M: Bactericidal effects and cytotoxicity of new aromatic dialdehyde disinfectants (ortho-phthalaldehyde). Biocontrol Sci, 16(4):165-170, 2011
  85. Ayaki M, Iwasawa A, Niwano Y: Cytotoxicity assays of new artificial tears containing 2-methacryloyloxyethyl phosphorylcholine polymer for ocular surface cells. Jpn J Ophthalmol, 55(5):541-546, 2011
  86. Sato E, Mokudai T, Niwano Y, Kohno M: Kinetic analysis of reactive oxygen species generated by the in vitro reconstituted NADPH oxidase and xanthine oxidase systems. J Biochem, 150(2):173-181, 2011
  87. Mokudai T, Kohno M, Niwano Y: Determination and speciation of vanadium(IV) and vanadium(V) in water sample by ion chromatography in combination with electron spin resonance analysis and/or electrolysis-induced reduction of vanadium(V). J Funct Water, 6(1):27-33, 2011
  88. Kohno M, Mokudai T, Ozawa T, Niwano Y: Free radical formation from sonolysis of water in the presence of different gases. J Clin Biochem Nutr, 49(2):96-101, 2011
  89. Nakamura K, Ishiyama K, Ikai H, Kanno T, Sasaki K, Niwano Y, Kohno M: Reevaluation of analytical methods for photogenerated singlet oxygen. J Clin Biochem Nutr, 49(2):87-95, 2011
  90. Niwano Y, Saito K, Yoshizaki F, Kohno M, Ozawa T: Extensive screening for herbal extracts with potent antioxidant properties. J Clin Biochem Nutr, 48(1):78-84, 2011
  91. Ikai H, Nakamura K, Shirato M, Kanno T, Iwasawa A, Sasaki K, Niwano Y, Kohno M: Photolysis of hydrogen peroxide, an effective disinfection system via hydroxyl radical formation. Antimicrob Agents Chemother, 54:5086-5091, 2010
  92. Tada M, Kohno M, Kasai S, Niwano Y: Generation mechanism of radical species by tyrosine-tyrosinase reaction. J Clin Biochem Nutr, 47:162-166, 2010
  93. Nakamura K, Kanno T, Ikai H, Sato E, Mokudai T, Niwano Y, Ozawa T, Kohno M: Reevaluation of quantitative ESR spin trapping analysis of hydroxyl radical by applying sonolysis of water as a model system. Bull Chem Soc Jpn, 83:1037-1046, 2010
  94. Nakamura K, Kanno T, Mokudai T, Iwasawa A, Niwano Y, Kohno M: A novel analytical method to evaluate directly catalase activity of microorganisms and mammalian cells by ESR oximetry. Free Radic Res, 44:1036-1043, 2010
  95. Kim D, Cha SH, Sato E, Niwano Y, Kohno M, Jiang Z, Yamasaki Y, Matsuyama Y, Yamaguchi K, Oda T: Evaluation of the potential biological toxicities of aqueous extracts from red tide phytoplankton cultures in in vitro and in vivo systems. J Toxicol Sci, 35:591-599, 2010
  96. Nakashima T, Seki T, Matsumoto A, Miura H, Sato E, Niwano Y, Kohno M, Ōmura S, Takahashi Y: Generation of Reactive Oxygen Species from conventional laboratory media. J Biosci Bioeng, 110:304-307, 2010
  97. Tada M, Kohno M, Niwano Y: Scavenging or quenching effect if melanin on superoxide an5ion and singlet oxygen. J Clin Biochem Nutr, 46:224-228, 2010
  98. Beppu F, Niwano Y, Sato E, Kohno M, Tsukui T, Hosokawa M, Miyashita K: In Vitro and in vivo evaluation of mutagenicity of fucoxanthin and Its metabolite fucoxanthinol. J Toxicol Sci, 34:693-698, 2009
  99. Beppu F, Niwano Y, Tsukui T, Hosokawa M, Miyashita K: Single and repeated oral dose toxicity study of fucoxanthin, a marine carotenoid, in mice. J Toxicol Sci, 34:501-510, 2009
  100. Iwasawa A, Saito K, Mokudai T, Kohno M, Ozawa T, Niwano Y: Fungicidal action of hydroxyl radicals generated by ultrasound in water. J Clin Biochem Nutri, 45:214-218, 2009
  101. Tada M, Ichiishi E, Saito R, Emoto N, Niwano Y, Kohno M: Myristic acid, a side chain of phorbol myristate acetate (PMA), can activate human polymorphonuclear leukocytes to produce oxygen radicals more potently than PMA. J Clin Biochem Nutr, 45:309-314, 2009
  102. Iwasawa A, Saito K, Mokudai T, Kohno M, Ozawa T, Niwano Y: Fungicidal action of hydroxyl radicals generated by ultrasound in water. J Clin Biochem Nutr, 45:214-218, 2009
  103. Iwasawa A, Niwano Y, Mokudai T, Kohno M: Antiviral activity of proanthocyanidin against feline calicivirus used as a surrogate for noroviruses, and coxsackievirus used as a representative enteric virus. Biocontrol Sci 14:107-111, 2009
  104. Niwano Y, Beppu F, Shimada T, Kyan R, Yasura K, Tamaki M, Nishino M, Midorikawa Y, Hamada H: Extensive screening for plant foodstuffs in Okinawa, Japan with anti-obese activity on adipocytes in vitro. Plant Foods Hum Nutr, 64:6-10, 2009
  105. Niwano Y, Adachi T, Kashimura J, Sakata T, Sasaki H, Sekine K, Yamamoto S, Yonekubo A, Kimura S: Is Glycemic Index of Food a Feasible Predictor of Appetite, Hunger, and Satiety? J Nutr Sci Vitaminol, 55:201-207, 2009
  106. Kohno M, Sato E, Yaekashiwa N, Mokudai T, Niwano Y: Proposed Mechanisms for HOOOH Formation in Two Typical Enzyme Reactions Responsible for Superoxide Anion Production in Biological Systems. Chem Lett, 38:302-307, 2009
  107. 樫村淳、足立堯、木下真紀、坂田隆、佐々木一、高橋英樹、中村義幸、庭野吉己、根崎裕子、福原公昭、夜久俊治、米久保明得、木村修一：果糖と脂質代謝　－特に肥満との関係を中心として－．日本食品新素材研究会誌 12:49-55, 2009
  108. Saito K, Kohno M, Yoshizaki F, Niwano Y: Antioxidant properties of herbal extracts selected from screening for potent scavenging activity against superoxide anions. J Sci Food Agric, 88:2707-2712, 2008
  109. Kohno M, Takeda M, Niwano Y, Saito R, Emoto N, Tada M, Kanazawa T, Ohuchi N, Yamada R: Early diagnosis of cancer by detecting the chemiluminescence of hematoporphyrins in peripheral blood lymphocytes. Tohoku J Exp Med, 216:47-52, 2008
  110. Sato E, Mokudai T, Niwano Y, Kamibayashi M, Kohno M: Existence of a New Reactive Intermediate Oxygen Species in Hypoxanthine and Xanthine Oxidase Reaction. Chem Pharm Bull, 56:1194-1197, 2008
  111. Nakashima T, Niwano Y, Takeshita S:Effects of antifungal agents on the red tide phytoplankton –possibility of a novel preventive tool- Aquaculture Res 39:1346-1350, 2008
  112. Saito K, Kohno M, Yoshizaki F, Niwano Y: Extensive screening for edible herbal extracts with potent scavenging activity against superoxide anions. Plant Foods Hum Nutr, 63:65-70, 2008
  113. Nakashima T, Iwashita T, Fujita T, Sato E, Niwano Y, Kohno M, Kuwahara S, Harada N, Takeshita S, Oda T: A prodigiosin analogue inactivates NADPH oxidase in macrophage cells by inhibiting assembly of p47phox and Rac. J Biochem, 143:107-115, 2008
  114. Sato E, Kohno M, Nakashima T, Niwano Y: Ciclopirox olamine directly scavenges hydroxyl radical. Int J Dermatol, 47:15-18, 2008
  115. Niwano Y, Mitsui G, Kohno M: Chemokines and their receptors as a target for the treatment of contact hypersensitivity. J Anti-Inflamm Anti-Allergy Agents Med Chem, 7:45-51, 2008
  116. Sachindra NM, Sato E, Maeda H, Hosokawa M, Niwano Y, Kohno M, Miyashita K: Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin abd its metabolites. J Agric Food Chem, 55:8516-8522, 2007
  117. Kim D, Nakashima T, Matsuyama Y, Niwano Y, Yamaguchi K, Oda T: Presence of the distinct systems responsible for superoxide anion and hydrogen peroxide generation in red tide phytoplankton Chatonella marina and Chatonella ovata. J Plankton Res29:241-247, 2007
  118. Sato E, Niwano Y, Mokudai T, Kohno M, Matsuyama Y, Kim D, Oda T: A Discrepancy in Superoxide Scavenging Activity between the ESR-Spin Trapping Method and the Luminal Chemiluminescence Method. Biosci Biotechnol Biochem, 71:1505-1513, 2007
  119. Niwano Y, Sato E, Kohno M, Matsuyama Y, Kim D, Oda T: Antioxidant Properties of the Aqueous Extracts from Red Tide Plankton Cultures. Biosci Biotechnol Biochem, 71:1145-1153, 2007
  120. Sato E, Niwano Y, Matsuyama Y, Kim D, Nakashima T, Oda T, Kohno M: Some Dinophycean Red Tide Plankton Species Generate a Superoxide Scavenging Substance. Biosci Biotechnol Biochem, 71:704-710, 2007
  121. Sato E, Kato M, Kohno M, Niwano Y: Clindamycin phosphate scavenges hydroxyl radical Int J Dermatol, 46:1185-1187, 2007
  122. Nakashima T, Sato E, Niwano Y, Kohno M, Muraoka W, Oda T: Inhibitory or scavenging action of ketoconazole and ciclopirox olamine against reactive oxygen species released by primed inflammatory cells. Br J Dermatol, 156:720-727, 2007
  123. Sato E, Kohno M, Niwano Y: Increased level of tetrahydro-β-carboline derivatives in short-term fermented garlic. Plant Foods Hum Nutr, 61:175-178, 2006
  124. Sato E, Kohno M, Hamano H, Niwano Y: Increased anti-oxidative potency of garlic by spontaneous short-term fermentation. Plant Foods Hum Nutr, 61:157-160, 2006
  125. Nishizawa M, Kohno M, Nishimura M, Kitagawa A, Niwano Y: Presence of peroxyradicals in cigarette smoke and the scavenging effect of shikonin, a naphthoquinone pigment. Chem Pharm Bull, 53:796-799, 2005
  126. Nishizawa M, Kohno M, Nishimura M, Kitagawa A, Niwano Y: Non-reductive scavenging of 1,1-diphenyl-2-picrylhydrazyl (DPPH) by peroxyradical –A useful method for quantitative analysis of peroxyeradical-. Chem Pharm Bull, 53:714-716, 2005
  127. Nimura K, Niwano Y, Ishizuka S, Fukumoto R: Actin gene-targeted RT-PCR could be a useful method for evaluating fungicidal activity against dermatophyte in vitro. J Int Med Res, 31:407-412, 2003
  128. Mitsui G, Mitsui K, Hirano T, Ohara O, Kato M, Niwano Y: Kinetic profiles of sequential expressions for chemokine genes in mice with contact hypersensitivity. Immunol Lett, 86:191-197, 2003
  129. Niwano Y, Ohmi T, Seo A, Kodama H, Koga H, Sakai A: Lanoconazole and its related optically active compound NND-502: Novel antifungal imidazoles with a ketene dithioacetal structure. Curr Med Chem–Anti-Infect Agents-, 2:147-160, 2003
  130. Nimura K, Niwano Y, Ishizuka S, Fukumoto R: Comparison of in vitro antifungal activities of topical antimycotics launched in 1990’s in Japan. Int J Antimicrob Agents, 18(2):173-178, 2001
  131. Niwano Y, Koga H, Kodama H, Kanai K, Miyazaki T, Yamaguchi H: Inhibition of sterol 14α-demethylation of Candida albicans with NND-502, a novel optically active imidazole antimycotic agent. Med Mycol, 37:351-355, 1999
  132. Niwano Y, Kuzuhara N, Goto Y, Munechika Y, Kanai K, Kodama H, Yoshida M, Miyazaki T, Yamaguchi H: Efficacy of NND-502, a novel imidazole antimycotic agent, in experimental models of Candida albicans and Aspergillus fumigatus infections. Int J Antimicrob Agents, 12:221-228, 1999
  133. Niwano Y, Kuzuhara N, Kodama H, Yoshida M, Miyazaki T, Yamaguchi H: In vitro and in vivo antidermatophyte activities of NND- 502, a novel optically active imidazole antimycotic agent. Antimicrob Agents Chemother, 42:967-970, 1998
  134. Niwano Y, Koga H, Sakai A, Kanai K, Hamaguchi H, Uchida M, Tachikawa T: Wound healing effect of malotilate in rats. Arzneim Forsch/Drug Res, 46:450-455, 1996
  135. Niwano Y, Koga H, Kanai K, Hamaguchi H, Uchida M, Yamaguchi H: Wound healing effect of the new imidazole antimycotic lanoconazole in rats. Arzneim Forsch/Drug Res, 46:218-223, 1996
  136. 溜池あかね、許斐麻美、佐藤眞美子、石島早苗、庭野吉己、大隅正子:抗真菌剤ラノコナゾールのTrichophyton rubrum発育菌糸細胞壁に及ぼす影響の電子顕微鏡学的研究. 医真菌誌 37:251-261, 1996
  137. 庭野吉己、葛原直基、金井和夫、浜口洋、近江哲人: 外用抗真菌剤ラノコナゾールのin vitro抗菌活性　-最近上市された外用剤との比較および薬剤の角質吸着時の抗菌活性に関する検討-. 基礎と臨床30:123-130, 1996
  138. Niwano Y, Tabuchi T, Kanai K, Hamaguchi H, Uchida K, Yamaguchi H: Short-term topical therapy of experimental tinea pedis in guinea pigs with lanoconazole, a new imidazole antimycotic agent. Antimicrob Agents Chemother, 39:2353-2355, 1995
  139. 庭野吉己、田淵龍夫、金井和夫、浜口洋、内田勝久、山口英世: ラノコナゾール軟膏のモルモット体部白癬モデルにおける治療効果. Jpn J Antibiot, 48:150-154, 1995
  140. 庭野吉己、金井和夫、浜口洋、内田勝久、山口英世新規外用抗真菌剤ラノコナゾールの白癬菌に対するin vitro抗菌活性に関する若干の検討. Jpn J Antibiot, 48:146-149, 1995
  141. 庭野吉己、近江哲人、金井和夫、浜口洋、内田勝久、山口英世: ラノコナゾールのCandida albicans保存株および皮膚カンジダ症患者由来新鮮分離株に対するin vitro抗菌活性. Jpn J Antibiot, 48:140-145, 1995
  142. 庭野吉己：水虫は完治するか? 角質への高浸透性・高貯留性の抗真菌剤登場で治療に格段の進歩　化学と生物 33:489-491, 1995
  143. 庭野吉己、田淵龍夫、金井和夫、浜口洋、内田勝久、山口英世: ラノコナゾール難航のモルモット足白癬モデルにおける治療効果. Jpn J Antibiot, 47:1192-1195,1994
  144. Niwano Y, Seo A, Kanai K, Hamaguchi H, Uchida K, Yamaguchi H: Therapeutic efficacy of lanoconazole, a new imidazole antimycotic agent, for experimental cutaneous candidiasis in guinea pigs. Antimicrob Agents Chemother, 38:2204-2206, 1994
  145. Niwano Y, Hainen WB, Becker BA, Johnson HD: Suppressed lymphocyte blastogenesis in newborn goats subjected to maternal separation. Jpn J Zootech Sci, 61:1127-1130, 1990
  146. Niwano Y, Becker BA, Mitra R, Caldwell CW, Abdalla EB, Johnson HD: Suppressed peripheral blood lymphocyte blastogenesis in pre- and post-partal sheep by chronic heat-stress, and suppressive property of heat-stressed sheep serum on lymphocytes. Dev Com Immunol, 14:139-149, 1990
  147. Niwano Y, Hansen TR, Kazemi M, Malathy PV, Johnson HD, Roberts RM, Imakawa K: Suppression of T-lymphocyte blastogenesis by ovine trophoblast protein-1 and human interferonα may be independent of interleukin-2 production. Am J Reprod Immunol, 20:21-26, 1989
  148. Niwano Y, Konaka S, Uchida M, Sugimoto T: Activation of　mitochondrial functions by malotilate in relation to accelerated liver regeneration in partially hepatectomized rats. Jpn J Pharmacol, 42:525-529, 1986
  149. Niwano Y, Katoh M, Uchida M, Sugimoto T: Acceleration of liver regeneration by malotilate in partially hepatectomized rats. Jpn J Pharmacol, 40:411-415, 1986
  150. Niwano Y, Ishii T, Ishibashi T: Effect of pinealectomy on the porphyrin content of the Harderian gland in rats. Jpn J Zootech Sci, 55:894-896, 1984
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